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Most preclinical studies are conducted in young, healthy, genetically homogeneous male rodents, far removed from the heterogeneity of aging human populations with comorbidities such as hypertension, diabetes, or cerebrovascular disease

Avoid taking antihistamines 24 hours before treatment

Niacinamide, a form of vitamin B3, is a potent ingredient known for its brightening and anti-inflammatory properties

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However, excessive exposure or unfavorable particle surface valence can overwhelm this defense, triggering pro-inflammatory cytokine release and exacerbating cellular injury (93)

At the same time, those pursuing more intensive liver detoxification may require customized guidance from a healthcare provider