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This technique has been extended to the apo form of 2 -microtubulin [19] and a nuclear receptor, peroxisome proliferator activated receptor, in the apo and ligand-bound state [20]

The four nitrogen atoms and the carboxyl group in the acetic acid on the nitrogen atom can be coordinated with metal, which is a common class of bifunctional chelators

Three decades later, we are still teasing apart the details of this crucial physiological mechanism, now responsible for some of the most popular drugs in the world