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Long-term human data beyond 6 months remains limited, but preclinical toxicology studies in animals showed no concerning findings with chronic administration

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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in the patients treated with semaglutide injection (3%) compared to placebo (1.8%)

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Understanding these warning signs helps determine the right supplementation approach, from targeted B12 shots to comprehensive IV infusions