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This structural damage causes further mitochondrial failure and even more ROS leakage, creating a continuous "doom loop" of profound energy depletion, systemic inflammation, and the hallmark symptom of post-exertional malaise (PEM)
31 P magnetic resonance spectroscopy in Alzheimer's and Pick's disease Neurobiol Aging 1993
JMF4073 eliminates WT-Bcr-Abl-transformed myeloid cells in vitro and in vivo Since the balanced supply of dNTPs is critical for overcoming DNA damage and replication stress for cell survival, we then tested whether JMF4073 treatment could selectively suppress the growth of Bcr-Abl-transformed but not untransformed myeloid cells
The glutathione reductase enzyme utilizes FAD and NADPH as cofactors
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Bioinformatics 30 , 523530 (2014)
