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Additionally, the gastrointestinal (GI) absorption efficiencies and bloodbrain barrier (BBB) penetration capabilities were evaluated using the BOILED-Egg classification model, which categorizes the compounds according to their predicted passive absorption and central nervous system access based on the apparent polarity (TPSA) and lipophilicity (WLOGP) values ( Results ChE inhibitory effects of the phenolic compounds As shown in Table 1, all compounds from various chemical groups were tested against 10 mM of the ChEs, of which 12 compounds were able to inhibit AChE, while 8 compounds achieved BChE inhibition over 50%
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10.1172/jci.insight.85717 JCI Insight
This synergy may enhance overall antioxidant protection
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