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Research published in the Journal of the American Medical Association found that GLP-1 drug users faced a higher risk of gastroparesis compared to users of other weight loss medications or diabetes drugs

Rothberg AE, McEwen LN, Kraftson AT, et al

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Like GHRS-R1a, the G protein-coupled GLP-1 receptor (GLP-1R) is also expressed in various regions of the CNS, including the hypothalamus, thalamus, brainstem, and cortical regions such as the insula, opercular cortex, frontal pole, and paracingulate gyrus (Drucker, 2022