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In contrast, the outer mitochondrial membrane (OMM), which delimits the IMS and the cytosol, has a relatively smooth and homogenous structure, and is permeable to most ions and small uncharged molecules ( Figure 1 Consistent with its customary epithet as the powerhouse of the cell, mitochondria play a pivotal role in cellular bioenergetics, through the production of ATP via oxidative phosphorylation (OXPHOS) ( 2 and NADH ( 2 ), these complexes transport protons against a concentration gradient from the matrix to the IMS

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