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The practical advantages of topical: easy to apply, local delivery, lower systemic exposure, and you don't need a needle
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Abbreviations ALA: Alpha-lipoic acid ALP: Alkaline phosphatase ALT: Alanine aminotransferase AST: Aspartate aminotransferase COX: Cyclooxygenase FM: Flunixin meglumine Hb: Hemoglobin HMGB1: High mobility group protein B1 NF-kb: Nuclear factor kappa-b ROS: Reactive oxygen species TNF-: Total antioxidant capacity TNF-: Tumor necrosis factor-alpha References Kohn DF, et al
10.1136/thoraxjnl-2017-210305 251 ProwT.SalazarJ.RoseW.SmithJ.ReeceL.FontenotA.et al (2004)
In very high doses there is a potential for nausea and pain at the injection site
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