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This would seem to be a potentially fruitful area for further research since the major environmental risk factors for PDexposure to pesticides, trichloroethylene, and air pollutionare likely to have their effects on dopaminergic neurodegeneration via toxic effects of oxidative stress and inflammation 61

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349 Meanwhile, RA patients typically have lower antioxidants, such as GSH and GSH peroxidase, and treatment with methotrexate significantly changes oxidative stress indicators in RA patients