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![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://www.researchgate.net/publication/363201315/figure/fig3/AS:11431281082605778@1662084799021/Efficacy-of-tirzepatide-in-phase-2-GPGB-14-and-phase-3-SURPASS-1-to-5-15-19.png)
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First, it's important to note that data from human clinical trials involving ipamorelin is extremely limited
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs13300-024-01660-0/MediaObjects/13300_2024_1660_Fig3_HTML.png)
Proper peptide storage prevents degradation that reduces effectiveness
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://www.frontiersin.org/files/Articles/1453825/xml-images/fphar-15-1453825-g001.webp)
The pattern we see most often: patients start at 5 mg/mL during titration, then switch to 10 mg/mL at maintenance to reduce vial size and injection volume
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://www.nejm.org/cms/10.1056/NEJMoa2416394/asset/67482ba8-0712-42b2-8a78-c184135fcbe8/assets/images/large/nejmoa2416394_f1.jpg)
Intranasal administration is a common alternative
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://lookaside.fbsbx.com/lookaside/crawler/media/?media_id=1425010346325638)
Suppressed thyroid stimulating hormone levels after initiation of a subcutaneous GLP-1 receptor agonist in a post-thyroidectomy patient
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://www.researchgate.net/publication/338837366/figure/fig2/AS:11431281460652109@1748135096560/Efficacy-outcomes-of-treatment-with-tirzepatide-at-12weeks-treatment-A-HbA1c-B.png)
If you feel no change after an hour, tell your provider
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://miro.medium.com/0*8Lu0qUs1kt9cPCOs.png)
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