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Joint pain and muscle pain have also been reported, though these may be related to rapid body composition changes rather than direct drug effects

If switching from tirzepatide to retatrutide, start retatrutide at 2 mg regardless of your previous tirzepatide dose and titrate up on the standard schedule

REF-1593 1/2022

"I kind of feel stupid, I guess," Drong says

This three-pronged approach is what makes its weight loss numbers so much higher than previous generation compounds

Standard protocol: Cycle length: 34 weeks on, 4 weeks off minimum Some protocols: 21 days on, 4 weeks off (the "21-day cycle") More conservative: 2 weeks on, 4 weeks off Use the off-weeks to let receptor density recover