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ROS generated during aluminum stress formed toxic aldehydes in reaction with fatty acids and caused severe root growth inhibition

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Moreover, Largo, et al showed that treatment with GS suppressed IL-1-induced COX-2 expression through transcriptional downregulation and suppression of NF-B DNA binding activity in human chondrocytes 22 , and as well, decreased COX-2 expression on peripheral blood mononuclear cells in rabbits with atherosclerosis aggravated by chronic arthritis 32