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Supplementation with vitamin E may also be of benefit in children with sickle cell anemia, as one study showed that six weeks of alpha-tocopherol supplementation improved several metrics of diseases severity in this population (Jaja 2005)

Neural Regen Res 14(3):532541

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However, this amount is generally obtained through diet

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Subtle toxicities (like mitochondrial stress, hepatocellular changes, or rare vascular events) may manifest only over time