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"It should be used only for short periods to quell acute nausea, not chronically to permit rapid dose escalation

Water intake should increase to at least 80-100 ounces daily because dehydration is amplified when stomach emptying slows and can trigger false hunger signals or fatigue

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Abrupt jumps skip the tolerability buffer and are the most common cause of severe nausea

Some of the weight-lowering effects of GLP-1 receptor agonists have been attributed to interaction with 5-HT 2A Rs, but this idea has also been contended [46, 53]

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