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Duration: Two 26-week periods (weight loss and weight maintenance phases) Results: Fat Loss: Combination therapy led to greater fat loss than semaglutide alone

Accidentally injecting into muscle (intramuscular) or very shallow into the skin (intradermal) can affect how the drug is absorbed

ECM and Collagen-Focused Models: Frequently used in fibroblast systems that track collagen and matrix-related markers

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Together, they can support steady weight loss without extreme restriction

Although GLP-1RAs are generally well tolerated, they are associated with gastrointestinal symptoms, pancreatic complications, and occasionally retinopathy, renal events, or injection-site reactions (Table 1)