For the animal virulence testing, data were analyzed using the non-parametric MannWhitney U test, which is more appropriate for small sample sizes and does not assume normal distribution of the data
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Low levels of glutathione (GSH) increase oxidative stress, which can be particularly damaging to the brain and may accelerate the progression of certain health conditions
There is a preferential transport of GSSG from the cytosol to the endoplasmic reticulum to maintain an adequate environment for protein disulfide bond formation and protein folding ( Glutathione and the -glutamyl cycle The synthesis, transport and catabolism of GSH occur in a series of enzymatic steps and transports of membrane that are collectively called -glutamyl cycle (Figure 5) ( - glutamyl cycle was postulated by Meister (Figure 5)
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This upregulation extends to key antioxidant systems, including glutathione (GSH) and thioredoxin (TRX), which help maintain redox balance and support tumor survival [35]