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A lyophilized peptide that survives years in the freezer may last only weeks once reconstituted

Non-cleavable linkers, commonly including maleimide and thiolactam, facilitate the conjugation of payload with antibodies or peptides by forming an amide bond (as in the linker in Kadcyla in Figure 6) or a thioether bond (as in the linker in Blenrep in Figure 6)

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