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The compound requires subcutaneous administration for maximum bioavailability, as oral administration results in poor absorption due to first-pass metabolism

Conflicts of interest: none declared References Morse,H.N (1878)Ueber eine neue Darstellungsmethode der Acetylamidophenole[on a new method of preparing acetylamidophenol].Berichte der deutschen chemischen Gesellschaft.11(1):232-233.doi:10.1002/cber.18780110151 Ayoub SS, Botting RM, Goorha S, et al Acetaminophen-induced hypothermia in mice is mediated by prostaglandin endoperoxide synthase 1 gene-derived protein.Proc Natl Acad Sci USA.2004;101:11165-11169 Schilling A, Corey R, Leonard M, Eghtesad B.Acetaminophen:old drug, new warnings

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Do not wait for routine labs Severe abdominal pain, persistent vomiting, fainting, dehydration, chest pain, or allergic symptoms need medical review

In: Greshon S, Shopsin B (eds) Lithium: Its Role in Psychiatric Research and Treatments Plenum Press: New York 1973

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