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SIRT2, present both in nuclear and cytoplasmic compartments, can increase MFN2 and decrease DRP1, thus promoting mitochondrial fusion 104,105
This route enables gut-derived signals to rapidly influence microglial activation and neuroinflammation in areas like the substantia nigra (Table 2)
Diabetes and high blood pressure are the leading causes of CKD, so people with high blood pressure or blood glucose levels need to be particularly vigilant about monitoring their kidney function
Trzepacz et al., 2013)
2012;6(7):e1729
Balendiran, G
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