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"Some of this is related to changes in sleep, stress, physical activity levels, body composition, and nutrition, which are common [things that change] as people age," says Renae Thomas, MD, MPH, a Lifeforce Physician

Spry et al 48 demonstrated that chronic topical application of forskolin in MC1R-deficient mice led to epidermal thickening, attributed to the accumulation of nucleated keratinocytes, and increased melanocyte presence

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However, obesity specialists now estimate this figure may reach 20% in clinical practice