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IGF-1 LR3 Trials: IGF-1 LR3 itself is not FDA-approved for any human use
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They did however comment in their New England Journal of Medicine article that the affinity of lixisenatide for the GLP-1 receptor was up to four times greater than that of human GLP-1and there have been neuroprotective actions shown in animal models of Alzheimers disease. Together, I suspect these were likely strong rationales driving their choice of the use of Lixisenatide
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Tirzepatide (Zepbound / Mounjaro) Tirzepatide activates both GLP-1 and GIP receptors simultaneously a dual mechanism that produces significantly greater weight loss than GLP-1 alone
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