Genetic variants including GIPR rs1800437 , FTO rs9939609, and MC4R rs17782313 relate to the biological pathways these medications act on
J Amino Acids 2012:736837 Bella DL, Hirschberger LL, Kwon YH, Stipanuk MH (2002) Cysteine metabolism in periportal and perivenous hepatocytes: perivenous cells have greater capacity for glutathione production and taurine synthesis but not for cysteine catabolism
KaplanMeier survival analysis revealed that the IGH group exhibited significantly poorer survival outcomes compared to the IGL group, suggesting that GSH may contribute to neoadjuvant chemotherapy resistance and lead to a worse prognosis in breast cancer patients
These adverse effects, including peripheral neuropathy and hearing loss, can have a profound impact on patient quality of life and require careful monitoring throughout treatment [44, 45]
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