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Initially designed to treat diabetes, GLP-1 receptor agonistssuch as semaglutide (Ozempic, Wegovy) and liraglutide (Saxenda, Victoza)mimic the hormone glucagon-like peptide-1, which stimulates insulin production and helps lower blood sugar levels

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Zepbound's evidence comes from SURMOUNT-1, also published in NEJM (Jastreboff et al., 2022)