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Pegylation extends half-life from 2 hours (native IGF-1 Ec) to 24+ hours, reducing injection frequency while maintaining safety profile similar to parent peptide

Conclusions GLP-1 receptor agonists significantly reduce major cardiovascular events and mortality in high-risk populations, with a favourable long-term safety profile

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CFU numbers were corrected for if any dilutions were made to the supernatant or lysates before plating