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Instead, electrophysiological and behavioral experiments suggest that exendin-4 increases the activity of ventral striatal neurons and reduces food intake, respectively, via presynaptic GLP-1 receptors in glutamatergic neurons and subsequent postsynaptic AMPA receptor activation [103], analogous to the aforementioned mechanism in the VTA [99]

The quality of berberine studies is generally lower, with smaller sample sizes and shorter durations