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By the end of an 8-week supplementation with L-Carnitine-combination, total mTOR increased by 81% compared to the baseline without significantly affecting mTOR phosphorylation, as well as its downstream proteins, possibly because of the reported delay in the phosphorylation capacity of this protein kinase in the elderly [38]

Conclusion: We have demonstrated the promotive role of dietary factors in the development of central fatigue and have successfully established a more stable and clinically relevant animal model of central fatigue by integrating dietary and sleep factors

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10.1016/0009-3084(87)90064-8 Chem

Death was confirmed by cessation of respiration and heartbeat and absence of corneal reflex