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In individuals struggling with excess weight or obesity, these hormonal responses are thought to be impaired
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Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
In addition, cystinotic cells exposed to oxidative stress (hydrogen peroxide) were unable to increase their GSH concentration above baseline
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The model includes all three suggested insulin actions to control lipolysis: two direct actions, one anti-lipolytic via protein kinase B (PKB) activation of phosphodiesterase 3B (PDE3B) (action-1), one lipolytic via inhibition of PDE3B (action 2), and a third indirect anti-lipolytic action via -adrenergic receptors (action-3)
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