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For example, those with severe liver or kidney impairment, unstable heart disease, or other significant systemic illnesses are typically approached carefully if considering NAD+ therapy

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If you are like most people with thyroid disease then the answer is yes

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Do not use if you are allergic to any of the ingredients

The trial also reported secondary improvements in knee-pain scores, which matters for the eventual label scope but does not change the regulatory math for an obesity indication