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Chemist Derek Lowe, PhD, summarized the decades-long quest to find a cure for obesity as, for the most part, a bottomless pit into which people shove money and time. The demand for this kind of drug is overwhelming, according to Suneil Koliwad, MD, PhD, UCSFs chief of endocrinology and metabolism and an expert in diabetes and obesity

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doi: 10.1046/j.1464-5491.2001.00424.x 26 KendallDMRiddleMCRosenstockJZhuangDKimDDFinemanMSet al

Why that selectivity exists at the receptor level isnt entirely settled it may reflect biased agonism, where the specific binding geometry favors the somatotroph signaling pathway over the corticotroph one, even though both cell populations express GHSR-1a