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A 2021 review of 16 randomized trials found B12 does not reliably reduce fatigue in people who are not deficient
User 11 started at 250mcg daily for golfer's elbow and progressed to 1mg daily after finding insufficient response at the lower dose
Theres no universally best time, but most users inject: Once daily in the morning , or Split into two doses : AM and PM for more stable coverage (especially for injury or gut repair) For injury-specific cases, timing the dose post-workout or before sleep may support natural repair cycles
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Peptide therapy typically requires ongoing or periodic treatment to maintain benefits
