Taking a proton pump inhibitor or other medications that reduce stomach acid for reflux or ulcers, as well as taking metformin for diabetes, can reduce absorption of B12 in food or supplements
The answer depends on several factors including peptide type, molecular modifications (such as PEGylation), dosing frequency, and delivery route
For lots of people who suffer with severe acne problems, it's worth mentioning that this therapy isn't generally suggested
Turkish journal of urology
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People with Diagnosed B12 Deficiency or Anemia The most obvious candidates for B12 injections are individuals who have been diagnosed with a B12 deficiency or pernicious anemia