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The collapse of m not only reflects impaired electron transport and ATP synthesis but also serves as a molecular trigger for mitochondrial dysfunction and downstream apoptotic signaling (Liu et al., 2020)

doi: 10.1016/0003-9861(90)90635-C 33 HalliwellB

Efficacy and tolerability of tirzepatide, a dual glucosedependent insulinotropic peptide and glucagonlike peptide1 receptor agonist in patients with type 2 diabetes: a 12week, randomized, doubleblind, placebocontrolled study to evaluate different doseescalation regimens

Furthermore, GLP-1 and its analog (Ex-4) enhanced DNA repair and protected cortical neurons in brains of rats after ischemia which were due to up-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) mediated by PI3K/AKT/CREB pathway (100)

Additionally, GLP-1 helps with satiety, or the feeling of fullness, which can aid in reducing food intake

Responses on the other lever were recorded but produced no programmed consequence