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In bovine mammary-gland research, DES stimulated local cell proliferation at doses 10-fold lower than native IGF-1, demonstrating potency that is site-specific rather than systemic [11]

One of their key tools is the Poisons Standard, a legislative instrument that classifies substances into different schedules based on their risk profile and the level of control required to protect public health

The severity is dose-dependent

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We selected an adaptation of the KDIGO definition [31] of AKI as a novel primary efficacy endpoint to assess RBC function on the basis that AKI is relatively common after complex cardiac surgery

It rides on two carrier proteins, and the distinction between them explains most of the confusion around this test