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The other trial, the SYNCHRONIZE MASLD study had a co-primary endpoint of greater than 30% reduction in liver fat content as assessed by MRI, and those in Survodutide group, 84% met this criteria compared to just 24% placebo
Many patients report feeling hungrier more frequently and experiencing reduced feelings of fullness after meals
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CCK functions in an autocrine manner by binding to the cholecystokinin type A receptor (CCK-AR), inhibiting channel activation and increasing intracellular Ca2+ by up to 30% upon TAS2R stimulation (73)
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