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According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver
We believe in equipping families and teens with the why behind the what. When young people understand how their body works, they make better choices and feel more confident doing it
In this setting, metabolic durability may depend on maintaining cofactor availability within physiological ranges rather than pursuing aggressive replacement strategies
When a patient may have less weight to lose in general, or they are reluctant to be on longer-term medication, phentermine can be a good option, says Vukasinov
Semaglutide is FDA-approved for type 2 diabetes management (Ozempic, Rybelsus), cardiovascular risk reduction in patients with type 2 diabetes and established cardiovascular disease (Ozempic), chronic weight management in obesity or overweight with comorbidities (Wegovy), and cardiovascular risk reduction in adults with established cardiovascular disease and obesity or overweight (Wegovy)
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