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doi:10.1093/clinchem/42.3.416

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(2011) 6:e22623

The review also notes a temporary worsening of diabetes-related retinopathy during rapid glycemic improvement, an increased aspiration risk from delayed gastric emptying, and the need to protect against nutritional deficiencies and loss of muscle or bone mass during rapid weight loss

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Metformin and liraglutide have complementary mechanisms, and their combined use is supported by extensive clinical data