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9 Conclusion The favorable impacts of omega-3 PUFAs on the neurovascular microenvironment indicate their potential to influence neural and immune cells in the brain through various physical and biochemical pathways, leading to outcomes such as anti-inflammatory, anti-nociceptive, antioxidative, and mood regulation

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The hypertrophic heart can use lactate as fuel, export lactate to manage cytosolic redox state, or use lactate-derived signals to influence gene regulation

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Therefore, an increase in labile iron pool and lipid peroxidation are considered typical presentations of ferroptosis and are used as markers of ferroptotic cell death (Fig