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In some studies, the 5-lipoxygenase inhibitor zileuton, when co-administered with PGE2, reduced pulmonary bacterial burden and pathology and prevented acute death in M.tb -infected mice deficient in both IL1R1 and IFNAR1 [129]

Available from: Bossart M, Wagner M, Elvert R, Evers A, Hbschle T, Kloeckener T, et al

iNOS, Inducible Nitric Oxide Synthase

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An increase in major adverse cardiovascular events prompted the withdrawal of sibutramine in Europe and the US