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and I discuss a range of FDA developments on FDA Watch

By inhibiting oxidative phosphorylation (OXPHOS), which induces mitochondrial hyperpolarization and subsequently stimulates ROS production [23], the oxidation of palmitoylcarnitine (C16-carnitine) produces more ROS in mitochondria than carbohydrates [24]

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However, several factors can compromise carnitine status: caloric restriction (which reduces dietary intake), certain medications, chronic kidney disease, and strict vegetarian or vegan diets