What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: A randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial." The Lancet , 402(10404), 529-544
900 mg Dosage: Cost per injection starts at PKR 9,000
It also fights free radicals that cause skin pigmentation, blemishes, dark spots, and skin discoloration (1)
Furthermore, the high-dose group experienced a two-fold increase in Natural Killer (NK) cell immune cytotoxicity, proving that oral supplementation not only raises antioxidant levels but actively enhances immune defense mechanisms
Rolando Grave de Peralta Menendez and Sara Gonzalez Andino developed the LAURA source estimation methods applied here, and Christoph Michel provided additional analysis software
