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Week 1 through week 4: the initial adjustment phase The first month on GLP-1 therapy is equal parts exciting and uncomfortable

Crucial for breaking down food and repairing body tissues

Beyond weight loss, early exploratory data suggest potential benefits including: Reductions in HbA1c (a marker of blood sugar control) in people with type 2 diabetes Improvements in lipid profiles (cholesterol and triglycerides) Reductions in liver fat, which may be relevant for metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), though these findings are preliminary Possible cardiovascular benefits

Plasma levels returned to baseline within 24 hours

KARs activation in hippocampal inhibitory interneurons has been shown to reduce GABA release

"Sesames unique model allows us not only to make high-quality specialty care like weight loss much more accessible and affordable, but also to empower clinicians to create care plans that are specific toand appropriate foreach individual patient." New York City-based Sesame launched in 2019 to connect patients to in-person and virtual care using a direct-pay model