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This is educational reference material written to help readers interpret the science accurately
Rapid weight loss can reduce mechanical stress on bones and sometimes decrease nutrient intake, both of which can contribute to lower bone density
However, evidence suggests that maintaining weight loss without pharmacological support remains challenging for most people due to biological adaptations that defend against weight loss
Rappaport, A
Additionally, exenatide increased cerebral glucose metabolism in regions associated with glucose homeostasis, appetite, and food reward, as observed through [(18)F]2-fluoro-2-deoxy-d-glucose PET/CT scans [17,18,19]
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