glp-1 prebiotic Supergut Daily Support Unflavored digestion and heart health* GLP-1 Daily Support Prebiotic Fiber

2,3 Given the systemic benefits of GIP on macronutrient metabolism and energy consumption, partnering with GLP-1 can impact glycemic and weight loss goals for many patients

Direct mechanisms of tirzepatide on cardiovascular health Although the precise mechanism by which tirzepatide could benefit HF is not known, several potential pathways have been suggested: Anti-inflammatory effects Patients with T2DM experience increased levels of hyperinsulinemia, hyperglycemia, and insulin resistance

Acknowledgements We acknowledge the support of the staff of the Pennsylvania State University College of Medicine Clinical Research Center and Investigational Pharmacy

A 2mL reconstitution that provides 40 research doses consumed daily runs through the vial in ~40 days (exceeding the 28-day refrigerated shelf life of reconstituted peptide)

Diabetes trials use blood-sugar control, where tirzepatides GIP-driven improvement in insulin sensitivity is most visible. Results from one population do not transfer cleanly to the other

In cases of drug-induced hepatotoxicity, dose adjustments, treatment discontinuation, or alternative therapies may be necessary