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It is acknowledged that the stimulation of signal transducers and activators of transcription 3 (STAT3) is essential for the transformation into the M2 subtype, whereas the activation of STAT1 is a crucial determinant for the M1 subtype [85]

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Minor side effects can include: A bit of tenderness, puffiness, or pink discoloration right around the puncture A brief warm or flushed sensation Mild headache or nausea Reach out to a medical professional right away if you notice: Redness that keeps spreading, heat, or discharge near the site (possible infection) Hives, facial swelling, or difficulty breathing (possible allergic reaction) Persistent numbness or tingling that spreads beyond the site Fever or chills within 48 hours of injection Safe Needle Disposal and Storage A proper FDA-cleared sharps bin is ideal

Histological analysis Synovial tissues were fixed in 4% paraformaldehyde, paraffin-embedded, and then transversely sectioned for routine HE staining