Presentations at the most recent ADA scientific sessions in 2024 included discussions of clear benefits to reduce liver fat in MASH (formerly called NAFLD) with tirzepatide (Loomba, NEJM, 2024) and a phase 2 trial with the triagonist (GLP-1/GIP/Glucagon), retatrutide (Sanyal, Nature Medicine, 2024)
Lanifibranor is a small-molecule pan-PPAR agonist (activates PPAR, , and ) developed by the French biotech Inventiva
10.1136/bmj.k1497 40 YangB.LiS.ChenZ.FengF.HeL.LiuB.et al (2020)
We believe that this soap will become the cleanser of choice for millions of women and men looking for brighter, healthier, & younger looking skin
doi:10.1089/ars.2017.7136
Lifestyle Optimization Maximize results by optimizing these factors: Nutrition: Adequate protein (1.6-2.2g per kg bodyweight) Moderate carbohydrates timed around training Healthy fats for hormone production Micronutrient-dense whole foods Strategic caloric deficit for fat loss goals Training: Resistance training 3-5x per week Progressive overload principles Adequate recovery between sessions HIIT or cardio for cardiovascular health Mobility and flexibility work Sleep: 7-9 hours nightly Consistent sleep schedule Dark, cool sleeping environment Minimize blue light exposure before bed Consider sleep tracking for optimization Stress Management: Regular meditation or mindfulness practice Adequate rest days Stress-reduction techniques Work-life balance Social connection and support Supplements to Consider Support peptide effectiveness with targeted supplementation: Vitamin D3 : 2,000-5,000 IU daily (test and optimize levels) Magnesium : 400-600mg daily (glycinate or threonate forms) Zinc : 15-30mg daily (especially for men) Omega-3s : 2-4g EPA/DHA daily Digestive enzymes : Support nutrient absorption Probiotics : Gut health optimization Exploring comprehensive wellness protocols through resources like applied wellness research with peptides provides additional context for holistic optimization
