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We were able to inhibit the synthesis of endogenous carnitine using MD and thereby establish a low-carnitine model in the zebrafish and tilapia in our previous studies ( Reference Li, Li and Qin 32 , Reference Pan, Li and Li 34 )

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It is a systemic input that improves the underlying biology supporting hair growth: protein synthesis, tissue repair, sleep quality (which influences hair growth cycles), and the anabolic state that supports anagen phase maintenance

TDM has been, almost exclusively, investigated for anti-TNF- therapy, and applied in IBD to a much greater extent than in other IMIDs

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Indeed, the latter experience early LV remodelling related to increased intra-cardiac pressures and without marked LVEF decline