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Biological characteristics of GLP-1RAs Molecular structure and pharmacological properties Due to the suboptimal in vivo stability of the native GLP-1 peptide, GLP-1RAs were engineered with structural modifications that mimic endogenous GLP-1 while achieving a prolonged duration of action [15]

Regular follow-up appointments, typically scheduled every 4 to 12 weeks during the initial treatment phase, allow for dose adjustments, side effect management, and monitoring of therapeutic outcomes

In contrast, the moderator test for the duration was non-significant ( P = 0.19)

Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

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For detailed peptide storage information, see our peptide storage guide