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Furthermore, ~324 of the 1431 upregulated genes in Trim37 ko3 PGCs, including Chpf , Obsl1 , and Rnf122 , exhibited open chromatin regions and loss of TRIM28 binding in their regulatory regions (Fig

Despite its critical importance, supplementing with standard oral glutathione has historically been highly ineffective

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4e and Supplementary Data 3), just as occurred in Gclc -sufficient MZB (Fig