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While it may seem surprising that treating diabetes would worsen one of the diseases complications, this seemingly paradoxical relationship is well-established: any treatment that abruptly lowers blood glucose can accelerate DR

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indeed, the overall cardiovascular safety profile remains favourable

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The case for stacking them rests on a single observation: the four receptor systems involved GLP-1, GIP, glucagon, and amylin are all non-overlapping

Effect of Semaglutide on Coronary Atherosclerosis Progression in Patients with Type II Diabetes: Rationale and Design of the Semaglutide Treatment on Coronary Progression Trial