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Transcriptome profiling of human post-mortem tissues (obtained from people aged between 16 and 102 years) found prominent and complex changes in gene expression in oligodendrocytes and astrocytes, whereas the neuronal transcriptome remained more or less undisturbed

667 Controlled cortical impact results in increased expression of ACSL4 and ALOX15, as well as ipsilateral cortical GSH consumption, suggesting that the ferroptosis pathway may be a valuable therapeutic target after TBI

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PMID: 30903796

Patients in the compounded group were more likely to be female (78.9% vs 64.2%) and younger (mean age 50.7 vs 56.3 years)

PMID: 18601945 | DOI: 10.1016/j.mam.2008.05.005 [24] Paur I, Balstad TR, Blomhoff R